:root {
  --report-link: var(--dl-accent);
  --report-chart-bg: var(--dl-color-brand-navy);
  color-scheme: dark;
}
:root[data-theme="light"] {
  --report-link: var(--dl-color-brand-navy);
  color-scheme: light;
}
* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 32px; }
body { margin: 0; background: var(--dl-bg); color: var(--dl-fg); font-family: var(--dl-font-family-sans); font-size: 16px; line-height: 1.65; -webkit-font-smoothing: antialiased; }
a { color: var(--report-link); text-underline-offset: 4px; }
a:hover { text-decoration-thickness: 2px; }
a:focus-visible, button:focus-visible, input:focus-visible, select:focus-visible, summary:focus-visible { outline: 3px solid var(--dl-accent); outline-offset: 5px; }
.wrap { width: min(1152px, calc(100% - 80px)); margin-inline: auto; }
p { margin: 0 0 18px; }
p:last-child { margin-bottom: 0; }
.muted { color: var(--dl-fg-muted); }
.small { font-size: 12px; line-height: 1.65; }
.eyebrow, .step { font-family: var(--dl-font-family-mono); text-transform: uppercase; font-size: 11px; font-weight: 500; letter-spacing: .1em; line-height: 1.4; color: var(--dl-accent); }
.eyebrow { display: block; margin: 0 0 16px; }
h1, h2, h3, .disclosure-title { font-family: var(--dl-font-family-display); }
h1 { font-size: clamp(48px, 5.15vw, 70px); font-weight: 700; letter-spacing: -.055em; line-height: 1.04; margin: 0 0 28px; }
h1 span { color: var(--dl-accent); }
h2 { font-size: clamp(30px, 3.5vw, 44px); font-weight: 600; letter-spacing: -.045em; line-height: 1.12; margin: 0; }
h3 { font-size: 21px; font-weight: 600; line-height: 1.25; letter-spacing: -.03em; margin: 0 0 10px; }
.masthead { display: flex; justify-content: space-between; align-items: center; gap: 28px; min-height: 116px; border-bottom: 1px solid var(--dl-border); }
.brand-lockup { display: block; padding-block: 18px; }
.brand-lockup img { display: block; width: 256px; height: auto; }
.light-logo { display: none !important; }
:root[data-theme="light"] .dark-logo { display: none; }
:root[data-theme="light"] .light-logo { display: block !important; }
.nav-actions { display: flex; align-items: center; gap: 26px; font-size: 12px; }
.nav-actions > a { color: var(--dl-fg-muted); text-decoration: none; }
button { font: inherit; cursor: pointer; }
.theme-toggle { background: transparent; color: var(--dl-fg-muted); border: 1px solid var(--dl-border); border-radius: var(--dl-radius-button); padding: 7px 10px; font-size: 11px; }
.dataset-notice { display: flex; gap: 22px; align-items: baseline; padding-block: 19px; color: var(--dl-fg-muted); }
.dataset-notice .eyebrow { flex-shrink: 0; margin: 0; font-size: 10px; }
.dataset-notice p { font-size: 11px; line-height: 1.6; }
.dataset-notice strong { font-weight: 500; color: var(--dl-fg); }
.dataset-notice a { white-space: nowrap; margin-left: 4px; }
.hero { display: grid; grid-template-columns: 1.05fr 1fr; gap: 54px; padding-top: 38px; padding-bottom: 50px; align-items: center; }
.dek { color: var(--dl-fg-muted); font-size: 18px; line-height: 1.65; max-width: 520px; }
.dek strong { color: var(--dl-fg); font-weight: 500; }
.hero-question { font-size: 15px; max-width: 490px; margin-top: 23px; }
.hero-actions { display: flex; gap: 26px; align-items: center; margin-top: 28px; }
.button { display: inline-flex; align-items: center; justify-content: center; gap: 12px; padding: 12px 18px; border: 1px solid transparent; border-radius: var(--dl-radius-button); font-size: 13px; font-weight: 600; text-decoration: none; }
.button.primary { background: var(--dl-accent); color: var(--dl-color-brand-navy); }
.button.primary:hover { background: var(--dl-color-brand-amber); }
.text-link { font-size: 12px; }
.hero-meta { color: var(--dl-fg-muted); font: 10px var(--dl-font-family-mono); margin-top: 25px; }
.lead-chart { margin: 0; border: 1px solid var(--dl-border); border-radius: var(--dl-radius-card); background: var(--report-chart-bg); padding: 24px 24px 22px; color: var(--dl-color-brand-paper); overflow: hidden; }
.chart-heading { display: flex; justify-content: space-between; align-items: baseline; gap: 20px; margin-bottom: 5px; }
.chart-heading .eyebrow { color: var(--dl-color-brand-amber-bright); margin-bottom: 0; }
.chart-heading strong { font: 500 24px var(--dl-font-family-display); letter-spacing: -.04em; }
.lead-chart img { display: block; width: 100%; height: auto; }
.lead-chart figcaption { border-top: 1px solid var(--dl-color-brand-slate); padding-top: 15px; margin-top: 4px; font-size: 12px; line-height: 1.7; color: var(--dl-color-brand-paper); }
.lead-chart figcaption strong { font-weight: 400; opacity: .72; }
.study-strip { display: flex; align-items: center; justify-content: space-between; gap: 25px; padding-block: 22px; border-block: 1px solid var(--dl-border); }
.study-strip span { font-size: 12px; color: var(--dl-fg-muted); }
.study-strip strong { color: var(--dl-fg); font-family: var(--dl-font-family-display); font-weight: 500; font-size: 24px; margin-right: 8px; }
.study-strip > a { font-size: 11px; white-space: nowrap; }
.section-nav { display: flex; gap: 32px; padding-top: 20px; overflow-x: auto; }
.section-nav a { font-size: 11px; color: var(--dl-fg-muted); text-decoration: none; white-space: nowrap; }
.section-nav a:hover { color: var(--report-link); }
.section { padding-block: 70px; }
.section-top { margin-bottom: 30px; }
.section-top .eyebrow { margin-bottom: 14px; }
.two-col { display: grid; grid-template-columns: 1fr 1fr; gap: 64px; }
.section-intro { font-size: 19px; line-height: 1.6; }
.narrow { max-width: 700px; }
.evidence-strip { display: grid; grid-template-columns: repeat(3, 1fr); gap: 25px; margin: 35px 0 22px; }
.evidence-strip div { border-top: 1px solid var(--dl-border); padding-top: 20px; }
.evidence-strip dt { font: 500 36px/1.2 var(--dl-font-family-display); font-variant-numeric: tabular-nums; letter-spacing: -.04em; margin-bottom: 9px; }
.evidence-strip dd { margin: 0; font-size: 12px; color: var(--dl-fg-muted); max-width: 230px; }
.quality-section { background: var(--dl-surface); border-block: 1px solid var(--dl-border); }
.quality-grid { display: grid; grid-template-columns: 1.15fr 1fr; gap: 58px; align-items: center; }
.quality-values { margin: 0; display: grid; grid-template-columns: 1fr 1fr; gap: 25px; }
.quality-values div { border-top: 1px solid var(--dl-border); padding-top: 17px; }
.quality-values dt { font: 500 40px/1.2 var(--dl-font-family-display); letter-spacing: -.04em; font-variant-numeric: tabular-nums; }
.quality-values dd { color: var(--dl-fg-muted); font-size: 12px; margin: 12px 0 0; max-width: 190px; }
.quality-limit { font-size: 13px; margin-top: 28px; color: var(--dl-fg-muted); }
.quality-limit strong { color: var(--dl-fg); font-weight: 500; }
details { border-bottom: 1px solid var(--dl-border); font-size: 14px; padding-block: 18px; }
summary { cursor: pointer; font-weight: 500; }
details[open] > summary { margin-bottom: 25px; }
.inline-detail { margin-top: 25px; font-size: 13px; }
.inline-detail summary { color: var(--report-link); }
.inline-detail blockquote { margin: 0 0 20px; max-width: 800px; font-size: 18px; line-height: 1.7; border-left: 2px solid var(--dl-accent); padding-left: 23px; }
.figure { margin: 24px 0; background: var(--report-chart-bg); color: var(--dl-color-brand-paper); border-radius: var(--dl-radius-card); padding: 20px; }
.figure img { display: block; width: 100%; height: auto; }
.figure figcaption { font-size: 11px; padding-top: 16px; color: var(--dl-color-brand-paper); }
.figure a { color: var(--dl-color-brand-amber-bright); }
.experiment-steps { display: grid; grid-template-columns: repeat(3, 1fr); list-style: none; gap: 30px; margin: 35px 0; padding: 0; }
.experiment-steps li { border-top: 1px solid var(--dl-border); padding-top: 20px; }
.experiment-steps .step { display: block; margin-bottom: 19px; }
.experiment-steps p { font-size: 14px; color: var(--dl-fg-muted); }
.experiment-note { display: flex; align-items: center; gap: 20px; padding: 22px 0; border-block: 1px solid var(--dl-border); }
.experiment-note img { flex-shrink: 0; }
.experiment-note p { font-size: 12px; color: var(--dl-fg-muted); }
.experiment-note strong { color: var(--dl-fg); font-size: 14px; font-weight: 500; }
.deep-dive { padding-bottom: 55px; }
.appendix { border-top: 1px solid var(--dl-border); border-bottom: none; padding-block: 25px; }
.appendix:last-child { border-bottom: 1px solid var(--dl-border); }
.appendix > summary { list-style: none; padding-right: 10px; }
.appendix > summary::-webkit-details-marker { display: none; }
.appendix summary .eyebrow { margin-bottom: 10px; font-size: 10px; }
.disclosure-title { display: flex; align-items: center; justify-content: space-between; font-size: 26px; line-height: 1.3; letter-spacing: -.035em; font-weight: 500; gap: 20px; }
.disclosure-title span { color: var(--dl-accent); font-size: 24px; transition: transform .15s; }
.appendix[open] > summary .disclosure-title span { transform: rotate(90deg); }
.disclosure-copy { display: block; font-size: 12px; color: var(--dl-fg-muted); margin-top: 9px; font-weight: 400; }
.method-content .section-heading { display: none; }
.method-content { padding-top: 22px; }
.method-content h3 { margin-bottom: 14px; }
.method-content p { font-size: 13px; }
.method-content .two-col { margin-bottom: 24px; }
code { font-family: var(--dl-font-family-mono); font-size: 11px; background: var(--dl-surface-raised); padding: 3px 5px; overflow-wrap: anywhere; }
.table-scroll { overflow-x: auto; }
table { border-collapse: collapse; width: 100%; font-size: 12px; text-align: left; }
caption { text-align: left; font-size: 11px; color: var(--dl-fg-muted); margin-bottom: 14px; }
th { font-weight: 500; }
th, td { padding: 12px; border-bottom: 1px solid var(--dl-border); font-variant-numeric: tabular-nums; vertical-align: top; }
thead th { color: var(--dl-fg-muted); font-size: 10px; }
.compact { margin-bottom: 20px; }
.explorer-controls { display: grid; grid-template-columns: 1.1fr 1.1fr 1fr auto; gap: 15px; align-items: end; margin-top: 28px; }
.explorer-controls label { display: block; font-size: 11px; }
input, select { display: block; width: 100%; margin-top: 7px; background: var(--dl-surface); color: var(--dl-fg); border: 1px solid var(--dl-border); border-radius: var(--dl-radius-button); font-family: var(--dl-font-family-sans); font-size: 12px; padding: 11px; min-height: 43px; }
input::placeholder { color: var(--dl-fg-muted); }
.download-link { font-size: 11px; padding-block: 10px; }
.explorer-grid { display: grid; grid-template-columns: 1.1fr 1fr; gap: 28px; margin-top: 24px; align-items: start; }
.gene-table-wrap { background: var(--dl-surface); border: 1px solid var(--dl-border); border-radius: var(--dl-radius-card); }
.gene-table { font-size: 11px; white-space: nowrap; }
.gene-table th, .gene-table td { padding: 10px; vertical-align: middle; }
.gene-table button { color: var(--report-link); border: 0; padding: 0; background: transparent; font: 500 11px var(--dl-font-family-mono); text-decoration: underline; text-underline-offset: 3px; }
.gene-table tr.selected { background: var(--dl-surface-raised); }
.gene-table tbody tr:hover { background: var(--dl-surface-raised); }
.pagination { display: flex; justify-content: space-between; align-items: center; gap: 12px; margin-top: 14px; font-size: 11px; }
.pagination button { padding: 7px 11px; border: 1px solid var(--dl-border); border-radius: var(--dl-radius-button); background: transparent; color: var(--dl-fg); }
.pagination button:disabled { opacity: .4; cursor: default; }
.gene-detail { border: 1px solid var(--dl-border); border-top: 2px solid var(--dl-accent); border-radius: var(--dl-radius-card); background: var(--dl-surface); padding: 24px; margin-top: 38px; }
.detail-heading { display: flex; align-items: start; justify-content: space-between; gap: 16px; }
.detail-heading .eyebrow { margin-bottom: 7px; font-size: 10px; }
.detail-heading h3 { font-size: 32px; margin-bottom: 18px; }
.status-pill { padding: 4px 8px; border: 1px solid var(--dl-border); border-radius: var(--dl-radius-badge); font-size: 9px; color: var(--dl-fg-muted); text-align: center; max-width: 110px; }
.detail-chart svg { width: 100%; height: auto; display: block; }
.detail-metrics { display: grid; grid-template-columns: 1fr 1fr; gap: 15px; margin: 24px 0; }
.detail-metrics div { border-top: 1px solid var(--dl-border); padding-top: 10px; }
.detail-metrics dt { font-size: 10px; color: var(--dl-fg-muted); }
.detail-metrics dd { margin: 6px 0 0; font-size: 16px; font-variant-numeric: tabular-nums; }
.downloads { display: grid; grid-template-columns: repeat(3, 1fr); gap: 18px; margin-block: 28px; }
.downloads a { text-decoration: none; border: 1px solid var(--dl-border); border-radius: var(--dl-radius-card); padding: 20px; }
.downloads strong { font-size: 12px; display: block; font-weight: 500; }
.downloads span { font-size: 11px; color: var(--dl-fg-muted); display: block; margin-top: 9px; }
.sources-title { margin-top: 32px; }
.sources { font-size: 12px; padding-left: 20px; }
.sources li { margin-bottom: 13px; padding-left: 5px; }
footer { padding-bottom: 35px; }
.footer-top { display: flex; align-items: center; justify-content: space-between; gap: 20px; margin-bottom: 20px; font-size: 11px; }
.footer-brand { font-family: var(--dl-font-family-display); font-size: 16px; color: var(--dl-fg); text-decoration: none; }
.footer-top > span { color: var(--dl-fg-muted); }
footer .small { font-size: 10px; }
.skip { position: absolute; top: -100px; left: 20px; background: var(--dl-accent); color: var(--dl-color-brand-navy); padding: 12px; z-index: 30; }
.skip:focus { top: 12px; }
.sr-only { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0,0,0,0); white-space: nowrap; border: 0; }
@media (max-width: 1000px) {
  .wrap { width: calc(100% - 48px); }
  .hero { gap: 28px; }
  h1 { font-size: 50px; }
  .lead-chart { padding: 18px; }
  .two-col, .quality-grid { gap: 30px; }
  .study-strip { gap: 18px; }
  .study-strip strong { font-size: 20px; margin-right: 4px; }
  .study-strip span { font-size: 11px; }
  .explorer-controls { grid-template-columns: 1fr 1fr; }
  .explorer-grid { grid-template-columns: 1fr; }
  .gene-detail { margin-top: 0; }
  .detail-chart { max-width: 620px; margin-inline: auto; }
  .detail-metrics { grid-template-columns: repeat(3, 1fr); }
}
@media (min-width: 701px) and (max-width: 850px) {
  .hero { grid-template-columns: 1fr; }
  .hero-copy { max-width: 650px; }
  .lead-chart { width: min(100%, 650px); }
}
@media (max-width: 700px) {
  .wrap { width: calc(100% - 36px); }
  .masthead { min-height: 90px; gap: 14px; }
  .brand-lockup img { width: 188px; }
  .nav-actions { gap: 13px; font-size: 11px; }
  .theme-toggle { font-size: 10px; padding: 6px 8px; }
  .dataset-notice { display: block; padding-top: 16px; }
  .dataset-notice .eyebrow { margin-bottom: 7px; }
  .dataset-notice p { font-size: 11px; }
  .hero { grid-template-columns: 1fr; padding-top: 25px; gap: 30px; padding-bottom: 30px; }
  h1 { font-size: clamp(34px, 10vw, 58px); margin-bottom: 22px; }
  h2 { font-size: 31px; }
  .dek { font-size: 17px; }
  .hero-question { font-size: 14px; }
  .hero-meta { margin-top: 22px; }
  .hero-actions { gap: 24px; }
  .lead-chart { padding: 20px; }
  .lead-chart img { max-width: 490px; margin-inline: auto; }
  .study-strip { flex-wrap: wrap; gap: 17px 22px; padding-block: 18px; }
  .study-strip span { font-size: 10px; }
  .study-strip strong { font-size: 21px; }
  .study-strip > a { display: none; }
  .section-nav { gap: 24px; padding-top: 17px; }
  .section-nav a { font-size: 10px; }
  .section { padding-block: 43px; }
  .section-top { margin-bottom: 24px; }
  .eyebrow { font-size: 10px; }
  .two-col, .quality-grid { grid-template-columns: 1fr; gap: 22px; }
  .section-intro { font-size: 17px; }
  .evidence-strip { grid-template-columns: 1fr; gap: 0; margin-top: 25px; }
  .evidence-strip div { display: flex; align-items: baseline; gap: 18px; padding-block: 16px; }
  .evidence-strip dt { font-size: 27px; min-width: 130px; margin: 0; }
  .evidence-strip dd { font-size: 11px; }
  .quality-values dt { font-size: 34px; }
  .experiment-steps { grid-template-columns: 1fr; gap: 0; margin-block: 26px; }
  .experiment-steps li { display: flex; gap: 20px; padding-block: 20px; }
  .experiment-steps .step { margin-top: 5px; }
  .experiment-steps h3 { font-size: 21px; }
  .experiment-note { gap: 12px; }
  .experiment-note img { width: 48px; height: 48px; }
  .experiment-note strong { font-size: 13px; }
  .experiment-note p { font-size: 11px; }
  .disclosure-title { font-size: 23px; }
  .disclosure-copy { font-size: 11px; }
  .explorer-controls { gap: 13px; }
  .explorer-controls label:first-child, .explorer-controls label:nth-child(2) { grid-column: 1/-1; }
  .gene-detail { padding: 20px 15px; }
  .gene-table th, .gene-table td { padding-inline: 8px; }
  .detail-metrics { grid-template-columns: 1fr 1fr; }
  .figure { padding: 10px; }
  .figure figcaption { font-size: 10px; padding: 12px 4px 4px; }
  .downloads { grid-template-columns: 1fr; gap: 12px; }
  .footer-top { flex-wrap: wrap; gap: 12px; font-size: 10px; }
  .footer-top > span { width: 100%; order: 3; }
  .footer-brand { font-size: 14px; }
}
@media (max-width: 380px) { .brand-lockup img { width: 165px; } .nav-actions { gap: 9px; } }
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } .disclosure-title span { transition: none; } }

.fit-note { border-left: 2px solid var(--dl-color-brand-slate); background: var(--dl-surface-raised); padding: 12px 14px; font-size: 12px; line-height: 1.65; margin-block: 15px; }